Ascophyllum nodosum seaweed review of published trials

Ascophyllum nodosum is a large, common, brown alga seaweed of the northern Atlantic Ocean, also known as Norwegian Kelp, Knotted Kelp, or knotted wrack. It is common on the north-western coast of Europe including and the north-eastern coast of North America. [2]

Effect of a Seaweed Extract on Fatty Acid Accumulation and Glycerol-3-Phosphate Dehydrogenase Activity in 3T3-L1 Adipocytes.
Lipids. 2009.  He ML, Wang Y, Mir PS, McAllister TA. Agriculture and Agri-Food Canada, Lethbridge Research Centre, Lethbridge, AB, Canada.
This study was to determine the effect of a seaweed Ascophyllum nodosum extract (SE) containing 220 mg g(-1) phlorotannins on differentiation and fatty acid accumulation in differentiating 3T3-L1 adipocytes. The results indicate that the biological factors in the Ascophyllum nodosum extract may be involved in differentiation and monounsaturated fatty acids accumulation in adipocytes.

Dietary Ascophyllum nodosum increases urinary excretion of tricarboxylic acid cycle intermediates in male Sprague-dawley rats.
J Nutr. 2009): Simmons-Boyce JL, Purcell SL, Nelson CM. National Research Council of Canada, Institute for Marine Biosciences, Halifax, NS, Canada B3H 3Z1.
We used a (1)H NMR-based metabonomics approach to examine the physiological effects of the seaweed Ascophyllum nodosum in a mammalian model, assess the dosage level required to elicit a response in the urinary profile, and identify potential toxic effects. Male Sprague-Dawley rats were fed a control or 5, 10, or 15% freeze-dried, ground A. nodosum diet for 4 wk. Urine samples were collected 3 times daily (0-4, 4-8, and 8-24 h) prior to feeding experimental diets and, at the end of the study, were profiled using (1)H NMR spectroscopy. Food intake, weight gain, and serum enzyme (alanine transaminase and aspartate transaminase) levels indicated that seaweed diets were well tolerated. The spectral data and principal component analysis (PCA) revealed that rats fed 5, 10, and 15% seaweed diets had increased urinary excretion of citrate, 2-oxoglutarate, succinate, trimethylamine (TMA), TMA-N-oxide, and malonate and decreased excretion of taurine, creatinine, and acetate compared with the controls. In addition, mannitol was detected in the 8- to 24-h urine samples from seaweed-fed rats. Metabolic responses related to ingestion of seaweed polyphenolics and fiber were not observed in the spectral profiles. Increased seaweed concentration in the diet did not increase the magnitude of the rats' response as detected by (1)H NMR. Visual analysis and PCA of the spectral data for serum samples collected at the end of the study did not show diet-related clustering. The lack of toxicity at 15% seaweed incorporation allows the use of this concentration in future A. nodosum intervention studies.

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