Sargassum fulvellum benefit and review of published studies

Sargassum fulvellum is a brown seaweed.

Fibrinolytic compounds isolated from a brown alga, Sargassum fulvellum.
Mar Drugs. 2009; Wu W, Hasumi K, Peng H, Wang X, Bao B. Department of Marine Biopharmacology, Shanghai Ocean University, Shanghai. China.
Two of bioactive natural products were founded in a brown alga, Sargassum fulvellum. After isolation and purification, the molecular structures of these two products were investigated by NMR spectroscopy and GC-mass spectroscopy. The two compounds were identified to be 1-O-palmitoyl-2-O-oleoyl-3-O-(alpha-D-glucopyranosyl)-glycerol (POGG) and 1-O-myristoyl-2-O-oleoyl-3-O-(alpha-D-glucopyranosyl)-glycerol (MOGG) which were obtained from Sargassum fulvellum for the first time. POGG and MOGG showed fibrinolytic activity in the reaction system of pro-u-PA and plasminogen.

Antipyretic, analgesic, and anti-inflammatory activities of the seaweed Sargassum fulvellum and Sargassum thunbergii in mice.
J Ethnopharmacol. 2008; Department of Biotechnology, Pukyong National University, Namku, Republic of Korea.
Dichloromethane, ethanol, and boiling water extracts of the brown seaweeds Sargassum fulvellum and Sargassum thunbergii were examined for antipyretic, analgesic, and anti-inflammatory activities in mice. The activities were evaluated against yeast-induced pyrexia, tail-flick test, and phorbol myristate acetate-induced inflammation (edema, erythema, and blood flow). The dichloromethane extract of Sargassum fulvellum inhibited an inflammatory symptom of mouse ear edema by 79%. The ethanol extract of Sargassum thunbergii also inhibited edema by 72%. No acute toxicity was observed after p.o. administration of each extract (5 g/kg bw). These findings are consistent with various claims that these seaweeds can be used as remedies for inflammation-related symptoms.

Vitamin B(12), a chlorophyll-related analog to pheophytin a from marine brown algae, promotes neurite outgrowth and stimulates differentiation in PC12 cells.
Cytotechnology. 2006; Ina A, Kamei Y. Coastal Bioenvironment Center, Saga University, Karatsu, Saga, Japan.
We previously isolated an analog to chlorophyll-related compounds, pheophytin a, from the marine brown alga Sargassum fulvellum and demonstrated that it is a neurodifferentiation compound. In the current study, we investigated the effects of the pheophytin a analog vitamin B(12) on PC12 cell differentiation. Our results suggest that vitamin B(12 )stimulates PC12 cell differentiation through enhancement of the mitogen-activated protein kinase signal transduction pathway, which is also induced by nerve growth factor. Thus, vitamin B(12) may be a good candidate for treatment of neurodegenerative diseases such as Alzheimer's disease.

Seaweeds include Laminaria sp., Sargassum fulvellum, Eisenia bicyclis and Gelidium species.

fucoxanthin benefit and side effects